KMID : 1041720220340010034
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Annals of Occupational and Environmental Medicine 2022 Volume.34 No. 1 p.34 ~ p.34
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The health effects of low blood lead level in oxidative stress as a marker, serum gamma-glutamyl transpeptidase level, in male steelworkers
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Lee Su-Yeon
Lee Yong-Jin Min Young-Sun Jang Eun-Chul Kwon Soon-Chan Lee In-Ho
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Abstract
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Background: This study aimed to investigate the association between lead exposure and serum gamma-glutamyl transpeptidase (¥ãGT) levels as an oxidative stress marker in male steelworkers.
Methods: Data were collected during the annual health examination of workers in 2020. A total of 1,654 steelworkers were selected, and the variables for adjustment included the workers¡¯ general characteristics, lifestyle, and occupational characteristics. The association between the blood lead level (BLL) and serum ¥ãGT level was investigated by multiple linear and logistic regression analyses. The BLL and serum ¥ãGT values that were transformed into natural logarithms were used in multiple linear regression analysis, and the tertile of BLL was used in logistic regression analysis.
Results: The geometric mean of the participants¡¯ BLLs and serum ¥ãGT level was 1.36 ¥ìg/dL and 27.72 IU/L, respectively. Their BLLs differed depending on age, body mass index (BMI), smoking status, drinking status, shift work, and working period, while their serum ¥ãGT levels differed depending on age, BMI, smoking status, drinking status, physical activity, and working period. In multiple linear regression analysis, the difference in models 1, 2, and 3 was significant, obtaining 0.326, 0.176, and 0.172 (all: p < 0.001), respectively. In the multiple linear regression analysis stratified according to drinking status, BMI, and age, BLLs were positively associated with serum ¥ãGT levels. Regarding the logistic regression analysis, the odds ratio of the third BLL tertile in models 1, 2, and 3 (for having an elevated serum ¥ãGT level within the first tertile reference) was 2.74, 1.83, and 1.81, respectively.
Conclusions: BLL was positively associated with serum ¥ãGT levels in male steelworkers even at low lead concentrations (< 5 ¥ìg/dL).
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KEYWORD
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Lead, Occupational exposure, Oxidative stress, Gamma glutamyl transpeptidase
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